Prime Minister Boris Johnson has tested positive for coronavirus.
Mr Johnson said he had developed mild symptoms over the past 24 hours, including a temperature and cough.
He is self-isolating in Downing Street but said he will “continue to lead the government’s response via video-conference as we fight this virus”.
Following Mr Johnson’s announcement, Health Secretary Matt Hancock also said he had tested positive for the virus.
Mr Hancock said his symptoms were also mild and he was working from home and self-isolating.
Mr Johnson was last seen on Thursday night, clapping outside No 10 as part of a nationwide gesture to thank NHS staff and carers.
In a video on his Twitter account, Mr Johnson, 55, said: “I’m working from home and self-isolating and that’s entirely the right thing to do.
“But, be in no doubt that I can continue thanks to the wizardry of modern technology to communicate with all my top team to lead the national fight-back against coronavirus.